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Maternal-Fetal MedicineSociety
SG-007GuidelineInfections

Infections in pregnancy: screening and management

Syphilis, hepatitis B, HIV, group B streptococcus, cytomegalovirus and toxoplasmosis — screening schedules and management algorithms.

Version 1.844 pagesUpdated 16 May 2025Infectious Diseases Working Group

Key recommendations

  • Universal screening for syphilis, HIV and hepatitis B at the first visit
  • GBS screening at 36–37 weeks
  • Indications for intrapartum antibiotic prophylaxis
  • CMV — targeted rather than universal screening

The document consolidates recommendations for screening and managing infectious disease during pregnancy.

Antibiotic prophylaxis

For GBS-positive patients, intrapartum prophylaxis should begin as early as possible after labour starts or membranes rupture.

Note: A guideline is a recommendation and does not replace the clinician's professional judgement in an individual case. Departing from it is acceptable where the reasoning is documented.